NOTCH3 and neoplasm: These genes included tumor markers (MUC16) [21, 22], genes that control tumor migration (MYL9) [23], metastasis (CEACAM6, VEGFC, CX3CL1, CST1, CCL5, S100A9, IGF1, NOTCH3) [24-35], cell adhesion (FN1, CEACAM1) [16, 36, 37], and inflammation (TRAF2, NF-κB2 and RelB) [38, 39] (Figure 5B).