Our sequence analysis results suggest that many critical cancer functions were changed in the highly metastatic cell line, including tumor markers (MUC16) [21, 22], genes that control tumor migration (MYL9) [23], metastasis ( CEACAM6, VEGFC, CX3CL1, CST1, CCL5, S100A9, IGF1, NOTCH3) [24-35], cell adhesion (FN1, CEACAM1) [16, 36, 37], and inflammation (NF-κB2, TRAF2, RelB) [38, 39]. The gene discussed is NOTCH3; the disease is cancer.