Throughout the experiment, real-time RT-PCR analysis and immunohistochemical (IHC) analysis of the pathologic sections of these tumors showed that SB-treated tumor had increased miR-494 expression (Figure 6E) and decreased Bmi1 and ADAM10 expression (Figure 6F) in comparison to those from control HNC-TICs tumors. The gene discussed is BMI1; the disease is neoplasm.