One haplotype defined by the rs2102808 minor allele (G>T) and a six base pair insertion in exon 1 of STK39 (del6, CGGGGC>-) was significantly associated with PD in the combined series (OR = 1.35, 95% CI: 1.11–1.64, P = 0.003, P corr = 0.02). Here, STK39 is linked to Parkinson disease.