CASP3 and cervical carcinoma: This compound is pro-apoptotic in human HeLa cervix carcinoma and SW1353 chondrosarcoma cells through the activation of caspase-3, caspase-8 and caspase-9, the down-regulation of Bcl-2, the up-regulation of Bax and the release of cytochrome c (cyt c) [55].