Sleep disturbance is a common features of autoimmune forms of encephalitis associated with antibodies to the voltage-gated potassium channel (VGKC) complex proteins, contactin-associated protein 2 (CASPR2), or leucine- rich glioma-inactivated 1 (LGI1), or to N-methyl-D-aspartate receptor (NMDAR) which are all proteins exposed on the surface of live neurons (reviewed in [14]). The gene discussed is LGI1; the disease is Autoimmunity.