HGF and neoplasm: The combination treatment with CPT-11 plus anti-HGF significantly inhibited tumor growth as compared to the control group, HCT-116 plus CCD-18co group and the HCT-116 plus CCD-18co treated with CPT-11 groups (1775.46 ± 257.53 mm3 versus 467.57 ± 81.90 mm3, p < 0.001; 2653.04 ± 396.62 mm3 versus 467.57 ± 81.90 mm3, p < 0.001; 850.38 ± 183.15 mm3 versus 467.57 ± 81.90 mm3, p < 0.05, respectively).