At the end of the experiment, tumor weight in the control, HCT-116 plus CCD-18co, HCT-116 plus CCD-18co with CPT-11, and HCT-116 plus CCD-18co with CPT-11 plus anti-HGF groups were 1.15 ± 0.27 g, 1.88 ± 0.31 g, 0.61 ± 0.20 g and 0.35 ± 0.15 g, respectively. This evidence concerns the gene HGF and neoplasm.