ChIP assay shows that HOXC8 binds to EMB promoter at the region from nucleotides −2303 to −2315, however, there are several putative HOX binding sites in this region, and there are other three regions of embigin promoter containing HOX binding sites, too (Figure 3A), suggesting that other HOX proteins may also take part in the regulation of embigin transcription in breast cancer cells. The gene discussed is HOXC8; the disease is breast carcinoma.