In clinically derived DTC isolated from the bone marrow, we validated that FN1 (p<0.01, from gene expression dataset GSE48995, [26]) and TGFB2 [35] were upregulated in patients with no evidence of disease when compared to patients with active PCa metastasis, whereas no significant gene expression change for CDC42 (p = 0.67) was detected between the two groups of DTC (data not shown). This evidence concerns the gene FN1 and posterior cortical atrophy.