Again, both PF956980 and PF1367550, inhibited both IFNγ-stimulated and IFNγ + TNFα-stimulated CXCR3 chemokine release from human primary airway epithelial cells in a concentration-dependent manner irrespective of the source of the primary airway epithelial cells (S2–S4 Figs, Table 4) with cells from non-smokers, smokers and COPD patients responding similarly. The gene discussed is TNF; the disease is chronic obstructive pulmonary disease.