CIMP positivity was defined as the presence of four or more of the six methylated promoters [CDKN2A (p16), IGF2, MINT1, MINT2, MINT31, and MLH1], which was detected in 13% of the rectal carcinoid tumors and was associated with lymphovascular invasion. The gene discussed is APBA1; the disease is rectal neuroendocrine tumor G1.