RUNX3 and rectal neuroendocrine tumor G1: With regard to the epigenetic alterations, CACNA1G, CDKN2A (p16), IGFBP7, IGF2, MGMT, MINT1, MINT2, MINT31, MLH1, RASSF2, and RUNX3 methylations were sequentially detected in 1 (1.8%), 18 (32%), 0 (0%), 7 (13%), 1 (1.8%), 28 (50%), 15 (27%), 34 (61%), 3 (5.4%), 1 (1.8%), and 0 (0%) rectal carcinoid tumors, respectively (Figure 1).