MLH1 and hyperplastic polyp: Regarding early colorectal neoplastic lesions, we recently reported that there was a progressive increase in the methylation status (i.e., CIMP status and MLH1 methylation) from hyperplastic polyps to SSA/Ps to SSA/Ps with cytological dysplasia [3], suggesting that accumulating epigenetic alterations may be associated with biological malignancy in serrated pathway progression.