To clarify the changes in B cell subsets and LRs and F-action expression pattern on B cells and determine the possible role of LEF in these changes in the patients with SLE, we measured CD19, CD38, CD95, CD27, IgD, GM1, and F-actin expression levels and their patterns on B cells from SLE patients. This evidence concerns the gene CD38 and systemic lupus erythematosus.