The CSF frequency of MOG-BBR was higher in both groups compared to the albumin-BBR frequency in CIS (Figure 6(b)) and circulating MOG-BBR (1.28 ± 0.11 and 0.57 ± 0.10%) in CIS patients and in the control group, respectively (P < 0.05) (Figure 6(c)). This evidence concerns the gene MOG and in situ carcinoma.