Assessment of frequency of memory (CD27+) and naïve (CD27−) B cells recognizing MOG-coated beads indicates 32.6 ± 3.16% CD27+ MOG-BBR and 64.86 ± 2.88% of CD27− MOG-BBR in MS patients versus 37.31 ± 3.84% of CD27+ MOG-BBR and 59.77 ± 4.02% of CD27− MOG-BBR in HI (Supplementary Figure 2b). Here, MOG is linked to myeloid sarcoma.