GDF15 and obesity due to melanocortin 4 receptor deficiency: GDF15(MIC1) rs1058587 C allele was nevertheless associated with minor frequency of smoking and obesity, lower BMI, and lower measurements of diastolic blood pressure (Table 4), whereas G allele was associated with earlier AOD, clinical cluster number 1, and positive ANA and it was inversely associated with SS and time cluster number 1.