GDF15(MIC1) rs1058587 C allele was nevertheless associated with minor frequency of smoking and obesity, lower BMI, and lower measurements of diastolic blood pressure (Table 4), whereas G allele was associated with earlier AOD, clinical cluster number 1, and positive ANA and it was inversely associated with SS and time cluster number 1. Here, BTG3 is linked to obesity due to melanocortin 4 receptor deficiency.