Infants who carry either the HLA-DR3 or DR4 alleles or who have a first-degree relative affected by CD [70] have a fivefold increased risk of developing CD autoimmunity with the presentation of positive tissue transglutaminase (tTG) autoantibody if they are exposed to gluten in the first three months of life. Here, TGM2 is linked to Autoimmunity.