PPARA and metabolic dysfunction-associated steatotic liver disease: Moreover, in another mice model of NAFLD, fructooligosaccharides (FOS) supplementation reduced hepatic triglyceride accumulation through changes in microbiota composition, thus leading to an increase in GLP-1, which stimulates fatty acid oxidation by peroxisome proliferator-activated receptor-alpha and lessened cholesterol accumulation by inhibiting sterol regulatory element binding proteins (SREBPs) [30].