Thus, it has been demonstrated that baculovirus recognition by TL9 leads to the production of various cytokines that triggers innate immunity, including IFNγ [23], which in turn has the potential to confer high levels of protection in several experimental models, such as influenza where intranasal immunization with a wild-type baculovirus protected 100% of mice from a lethal challenge [44]. Here, IFNG is linked to influenza.