NR3C2 and colitis: The transfer of F4/80+MR+ cells into DSS-treated mice was characterized by much less severe mucosal pathology than in mice that did not receive cells or mice that received F4/80+MR− cells, as evidenced by marked destruction of the crypt architecture and a greater influx of inflammatory polymorphonuclear cells, which are largely associated with colitis (Figures 8(c)-8(d)); thus mice receiving F4/80+MR− cells showed even worse pathology, with shorter colons and severe signs of cryptitis and loss of colon tissue architecture.