In fact, in a mouse model of imiquimod-induced psoriasis-like inflammation, topical curcumin was demonstrated to improve the skin lesions with an effect comparable to that of clobetasol and to significantly decrease the cutaneous levels of IL-17A, IL-17F, IL-22, IL-1β, IL-6, and TNF-α mRNA [41]. This evidence concerns the gene IL17A and psoriasis.