For the assessment of endothelial injury circulating endothelial cells (CECs), von Willebrand factor (vWF), and soluble thrombomodulin (sTM) were chosen as well established indicators since respective concentrations reflect the degree of endothelial injury associated with inflammation (vWF and sTM) and vascular damage (CECs) especially in patients with heart failure, diabetes, and various types of vasculitis [6–9]. This evidence concerns the gene VWF and heart failure.