Metastasis associated in colon cancer 1 (MACC1) was newly identified as an oncogene regulating the hepatocyte growth factor/met tyrosine kinase receptor epidermal growth factor (HGF/c-Met) pathway which is well recognized to promote carcinogenesis and tumor progression by facilitating migration and invasion as well as suppressing apoptosis of cancer cells [3]. Here, HGF is linked to neoplasm.