TNXB and melanoma: In one study tenascin-X null mice proved that absence of tenascin-X enhances invasion and metastasis in melanoma cells while in another study it was shown that tenascin-X can bind to both isoforms of vascular epidermal growth factor- (VEGF-) B and enhance the ability of VEGF-B to stimulate endothelial proliferation [23, 24].