A partial least squares discriminant analysis (PLS-DA) model based on MALDI-MS signals (24 peptide signals) containing some peptides of ApoA1 (oxidation at Met112), ApoC3 (upregulated), lipoprotein(a) (upregulated), and ApoC1 (downregulated) accurately classified CAD and control subjects [8]. Here, APOC1 is linked to coronary artery disorder.