FRK and central nervous system cancer: A series of protein kinases associated with glioma are studied including RTK (EGFR, ErbB2, ErbB3, IGF-IR, and KIT) [30–32, 38–40], Lyn kinase/Src kinase [41], Akt and focal adhesion kinase [27, 36, 37, 42, 43], Janus kianse [44], ABL2/ARG tyrosine kinase [45], ephrin family [46, 47], Fyn related kinase (FRK) [48], STAT-3 [49] and STAT-6 [23], Mer receptor tyrosine kinase [25], and VEGFR-2 tyrosine kinase [28].