In the US, acellular pertussis vaccines (DTaP) used consist of five Bp proteins, inactivated pertussis toxin (Ptx), filamentous hemagglutinin (FHA), pertactin (Prn), and fimbriae serotype 2 and/or 3 (Fim2/Fim3) which have been purified from the historic Bp strains, Tohama I (T) or 10536 [10–12]. The gene discussed is CIAO3; the disease is pertussis.