As expected, leptin levels were elevated in OB w.MetS and OB w.o.MetS versus CTR (p < 0.0001), while the anti-inflammatory ghrelin levels, though not showing any significant difference versus CTR, displayed clearcut in-between differences (p < 0.001) in the two OB subgroups (Figures 4(d) and 4(f)). The gene discussed is GHRL; the disease is metabolic syndrome.