These highly reactive products induce adipogenesis and fat production by adipocytes [65–67, 99–101], which creates a second self-sustained pathological loop of increased fat production and accumulation → increased fatty acid oxidation → chronic proinflammatory pattern formation → redox-dependent derangement of antioxidant and detoxifying systems → redox-dependent derangement of insulin sensitivity → redox-dependent dyslipidemia → MetS. The gene discussed is INS; the disease is metabolic syndrome.