INS and Hypoglycemia: Other reasons were the occurrence of hypoglycemia (5.4%), concern on possible adverse effects of rosiglitazone on the cardiovascular system (2.6%), patients' unwillingness to start insulin (1.6%), nonadherence to insulin (4 patients), difficulty in obtaining rosiglitazone (2 patients), and request by a patient who claimed that sitagliptin has better effect on his blood glucose.