We performed a randomized, crossover study, investigating in 20 in-patients with type 2 diabetes the effects of L-AGEs and H-AGEs meal on macrovascular (assessed by flow-mediated dilatation (FMD)) and microvascular (assessed by laser-Doppler flowmetry) function, serum markers of endothelial dysfunction (E-selectin, intracellular adhesion molecule 1, and vascular cell adhesion molecule 1), oxidative stress, and serum AGEs. The gene discussed is VCAM1; the disease is endothelial dysfunction.