Therefore, this study was aimed at investigating the daily fluctuation of PAI-1 activity in T2D and nondiabetic patients with previously diagnosed CAD and to examine the relationship of these fluctuations to the changes in plasma insulin, insulin resistance, glucose, and lipid as well as anthropometric parameters, previously suggested to be possible determinants of PAI-1 daily profile in those patients. This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.