We also found higher whole daily levels of PAI-1 (expressed as AUC of PAI-1), but in both diabetic and nondiabetic groups with CAD (group A and group C) in comparison to corresponding groups without CAD, while in patients with CAD the daytime PAI-1 levels were higher in T2D than in controls. The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.