FGF21 and hyperinsulinism: Further, as mentioned above, FGF21-treated bGH mice manifested a near normalization of the hyperinsulinemia (Table 1), which might explain the greater surge in blood glucose in the Tg-FGF21 group at 15 minutes (Figure 1(b), P < 0.05), relative to the Tg-vehicle-treated group, upon an exogenous glucose load.