INS and Hyperinsulinemia: FGF21 treatment did not affect fasted blood glucose levels in either group of animals; however, it was able to alleviate the hyperinsulinemia in the GH transgenic mice (PBS 2.56 ± 0.80 ng/mL and FGF21 1.00 ± 0.25 ng/mL; P < 0.005) without causing significant change in insulin levels in normal mice (PBS 0.86 ± 0.32 ng/mL and FGF21 0.97 ± 0.16 ng/mL).