We found the following: (1) resveratrol attenuated ConA-induced autoimmune hepatitis in mice, (2) resveratrol decreases TNFα, IL-2, and IL-6 expression in vivo, and (3) resveratrol may inhibit the release of Gli-1 and Ptc through modulation of the hedgehog signal pathway. This evidence concerns the gene GLI1 and autoimmune hepatitis.