Mechanisms that regulate the evasion of tumor cells by NK cells extends to the down-regulation of activating receptor ligands for NKG2D (69), the production of soluble stress-induced ligands, such as MICA, which degrades NKG2D leading to NK cell inhibition (70) and the release of suppressive cytokines such as IL-10 and TGF-β (71). Here, KLRK1 is linked to neoplasm.