Previous studies have established that the Fgf14−/− mouse model recapitulates an array of motor and cognitive phenotypes that are found in humans carrying the FGF14F145S mutation (Wang et al., 2002), the genetically inherited cause of SCA27 (van Swieten et al., 2003; Brusse et al., 2006). This evidence concerns the gene FGF14 and spinocerebellar ataxia type 27.