Alternatively, several studies suggest that the CX3CL1-CX3CR1 communication may be detrimental in rodent models of acute CNS injury such as stroke (reviewed in Sheridan and Murphy, 2013) and in the model requiring phagocytic activity of microglia [example, clearance of amyloid β (Aβ) plaques Fuhrmann et al., 2010; Lee et al., 2010a]. This evidence concerns the gene CX3CR1 and Stroke.