It is important to consider that in case of AD, tau hyperphosphorylation may be triggered by Aβ, either directly via the activation of protein kinases such as GSK3β (Ma et al., 2006) or through mediating neuroinflammation, which can then lead to tau pathology (reviewed in Bhaskar and Lamb, 2012). The gene discussed is WEE1; the disease is Alzheimer disease.