Notably, a previous study from our group has suggested that deficiency of CX3CR1 in the hTau mouse model of tauopathy resulted in accelerated tau pathology and cognitive impairment, which is mediated via IL-1β-p38 mitogen activated protein kinase (p38 MAPK) signaling pathway (Bhaskar et al., 2010). Here, MAPK14 is linked to Cognitive impairment.