While increasing evidence suggests that pathological modification of microtubule-associated protein, tau (MAPT), and neuroinflammation play a significant role in the neuronal loss observed in tauopathies (Ishizawa and Dickson, 2001; Gerhard et al., 2004, 2006; Wyss-Coray, 2006), the exact mechanism by which these two pathologies result in neurodegeneration remain unclear. This evidence concerns the gene MAPT and tauopathy.