By contrast, VPA-I can be considered as a group of orchids with optimal autism outcome; hyper-sensitive individuals that display extremely low emotionality and normal range of social and nociceptive behaviors, and an opposite level of many neurobiological proteins (e.g., highest levels of Amy GluN2B, S1 GluN2B, and dHip CaMKII and the lowest levels of plasma CORT, and vHip GluN1), when reared in an enriched and necessarily predictable environment. This evidence concerns the gene GRIN2B and autism.