In addition, it has been reported that, in fulminant type 1 diabetes, DNA methylation within the Foxp3 promoter impaired TLR9-induced FOXP3 expression by attenuating IRF-7 binding activity [23]. FCGR2A is the most widely expressed IgG receptors in various immune cells including natural killer cells, macrophages, and neutrophils [24]. The gene discussed is TLR9; the disease is type 1 diabetes mellitus.