Placenta-derived circulating factors could also stimulate proinflammatory cells to produce cytokines and chemokines, including IL-1beta, IL-2, IL-10, IL-12, IL-13, IL-18, granulocyte-colony stimulating factor (G-CSF), interferon- (IFN-) gamma, monocyte chemoattractant protein-1 (MCP-1), and TNF-alpha, demonstrating that preeclampsia is associated with an overall proinflammatory systemic environment [4–6]. This evidence concerns the gene CSF3 and preeclampsia.