Direct stimulation of the hypothalamus using kisspeptin administration offers an attractive novel potential avenue for treating patients with infertility, since it causes the release of an endogenous pool of GnRH, which in turn stimulates physiological levels of gonadotrophin secretion (Gottsch et al., 2004; Messager et al., 2005; Shahab et al., 2005). This evidence concerns the gene GNRH1 and Infertility.