Another point that deserves to be highlighted is that, apart from cases of fatal DKA in individuals with previously undiagnosed diabetes mellitus, numerous situations of forensic interest may concern unintentional mismanagement of medical treatment (either insulin or hypoglycemic agents) in diabetics due to impaired judgment and/or unconsciousness caused by concomitant drug (either recreational or therapeutic) intoxication or potentially incapacitating diseases. This evidence concerns the gene INS and diabetes mellitus.