We first performed an unsupervised cluster analysis of these MAP3K3 correlated (positive or negative correlated) genes together with MAP3K3 regulated genes (after MAP3K3 siRNA knockdown in H1299 and H838 cells), many cancer related pathways, ESC (embryonic stem cell), PRC2 (polycomb repressive complex 2), TGF-β regulated and EMT (epithelial-mesenchymal transition) related signatures42, 43. Here, TGFB1 is linked to cancer.