MAP3K3 and cancer: In our cluster analysis of MAP3K3-correlated genes with ESC, PRC2, EMT, TGF-β and other cancer-related pathways, we found that MAP3K3 positively correlated genes have the same expression pattern as PRC2 targets, T cell-related, TGF-β down regulated, increased differentiation and MAP3K3 up-regulated genes (in vitro, after MAP3K3 siRNA treatment) (Fig. 6A).