While global gene profiling studies on cells stably depleted of DFS70/LEDGFp75 failed to reveal a specific genetic pathway regulated by this protein [12], studies using pathway-specific gene arrays showed that ectopic overexpression or transient depletion of this protein in cancer cells under stress led to significant changes in the expression of certain stress and antioxidant genes [82]. This evidence concerns the gene PSIP1 and cancer.