To evaluate the epithelial-stromal self-loop relationships by an additional approach on independent samples, we identified the 38 proteins predicted by the epithelial-stromal co-expression network to be involved in statistically significant epithelial-stromal self-loops (FDR < 5 %) in both ER-positive and ER-negative IBC and not in normal breast. This evidence concerns the gene ESR1 and inflammatory breast carcinoma.