In ER-negative IBC, six of the top ten enriched signatures were breast cancer prognostic signatures, including chromosomal instability signatures (Carter 2006 (CIN 70); Carter 2006 (CIN 25)), a signature associated with prognosis in ER-positive breast cancer (Teschendorff 2006 (t52)), a signature associated with histologic grade in ER-positive breast cancer (Sotiriou 2006 (GGI)), a PTEN-associated signature (Saal 2007 (PTEN pathway)), and genes associated with TP53 mutation status in ER-negative breast cancer (Coutant 2011 (ER- 30 genes)). Here, PTEN is linked to breast cancer.