In summary, the transcriptome of post-mortem SN tissue of donors with Braak alpha-synuclein stages 0 to 6 revealed a consistent deregulation of pathways related to macroautophagy and protein synthesis, including EIF2 signaling, mTOR signaling and regulation of eIF4 and p70S6K signaling during the progression of PD pathology. Here, SNCA is linked to Parkinson disease.