RPS6KB1 and Parkinson disease: In summary, the transcriptome of post-mortem SN tissue of donors with Braak alpha-synuclein stages 0 to 6 revealed a consistent deregulation of pathways related to macroautophagy and protein synthesis, including EIF2 signaling, mTOR signaling and regulation of eIF4 and p70S6K signaling during the progression of PD pathology.