The results showed that DDX3 is a significant prognostic predictive indicator for colorectal cancer in both RNA sequencing (hazard ratio [HR] = 0.53, P = 0.039) and RNA microarray analysis (HR = 0.72, P = 0.026), and patients with low DDX3 expression had poor prognosis (Figure 1A and Supplementary Figure 1). This evidence concerns the gene DDX3X and colorectal cancer.