Consistent with the RPPA data, the combination induced strong downregulation of p-AKT, YAP1, p-YAP1 and p-PRAS40 protein expression in Me1007 and Patient-3-post cells and other melanoma cell lines, whereas no change in protein expression could be observed in melanocytes (Figure 5A, Supplementary Figure 4). Here, AKT1S1 is linked to melanoma.