The present finding of synergistic effects between these two classes of drugs are consistent with similar findings in studies on human acute myelogenous leukemia cells showing that the combination of the BET bromodomain inhibitor JQ1 and HDACi LBH589 was superior to treatment with either agent alone in inducing apoptosis and survival of NOD/SCID mice engrafted with acute myelogenous leukemia cells [23]. The gene discussed is DNER; the disease is acute myeloid leukemia.