As shown in Figure 6, HO-1 reduces the expression of ICAM-1 and CXCL10, which in turn inhibits the adhesion and recruitment of CXCR3-expressing Teff to CRC cells and consequently inhibits CXCR3-expressing Teff-mediated cytotoxicity against CRC cells. This evidence concerns the gene ICAM1 and colorectal carcinoma.