[23,26,27,42] In accordance with data from extensive studies on the dose-dependent effects and time kinetics of IM we applied lower IM doses (range: 1 μM to 2.5 μM) for leukemia-derived p210BCR-ABL-positive cells (KCL-22, BV-173, K562 and LAMA-84) than for p210BCR-ABL-negative cells (range: 2.5 μM to 10 μM). The gene discussed is ABL1; the disease is leukemia.