Our results provide a strong rationale for the ongoing study with APR-246 in combination with carboplatin and pegylated liposomal doxorubicin in patients with recurrent ovarian cancer expressing mutant p53, and suggest that combination treatment with APR-246 and platinum or other DNA-damaging drugs could allow dramatically improved therapy of a wide range of therapy-refractory human tumors carrying mutant p53. This evidence concerns the gene TP53 and ovarian cancer.