Mutant p53 often accumulates at high levels in cancer cells, which is believed to contribute to the strong apoptotic response upon APR-246 treatment.3 Strong synergy was also seen in the SCLC cell line NCI-H378 with the Y163C p53 mutation that is not considered as a hotspot mutation but still occurs frequently in tumors. Here, TP53 is linked to small cell lung carcinoma.