Therefore, the correlation between TAM density and the patient's prognosis is negative.78 The overexpression of CCL2 by murine fibrosarcoma cells resulted in an increase in TAMs numbers, which contributed to tumor growth in vivo.79 TAMs suppressed T-cell activation and proliferation by producing suppressive mediators, including IL-10 and TGF-β. This evidence concerns the gene TGFB1 and neoplasm.