These cells originate from myeloid tissue and are comprised of myeloid cell progenitors, precursors of DCs, monocytes, macrophages and granulocytes.82 They are typically CD11b+CD33+CD34+CD14-HLA-DR- cells in cancer patients, and are CD11b+Gr-1+ cells in tumor-bearing mice. This evidence concerns the gene ITGAM and neoplasm.