On the other hand, IL-10 also dampened anti-tumor immunity via an immunosuppressive role on DCs and macrophages.93 IL-10 induced PD-L1 expression on DCs, which in turn mediated the exhaustion process of T cells.86 Moreover, IL-10 has a significant role in the induction of Tregs.94 These findings demonstrate that IL-10 contributes to T-cell exhaustion in TME. The gene discussed is CD274; the disease is neoplasm.