Therefore, the impairment of synaptic plasticity is considered to cause cognitive deficits in an AD model mice.21 Indeed, PSD-95 deficiency was reported in Tg2576 mouse brains.46, 47 Along with PSD-95, MAP2 levels were enhanced by NSC transplantation, suggesting an increase of dendritic complexity. The gene discussed is DLG4; the disease is Cognitive impairment.