When osteopontin and osteoactivin were evaluated in the entire cohort of 60 patients with PsA and compared with 60 normal subjects and with 60 patients affected by RA and AS, osteoactivin was found to be statistically higher in subjects with PsA (Fig 5) with a high sensitivity and specificity (Fig 6). The gene discussed is GPNMB; the disease is rheumatoid arthritis.