However a recent work by Sherlock et al. [168,169]shows that IL-23 is able to induce enthesitis in animal models of spondyloarthropathy acting on resident T cells within the enthesis; once activated these entheseal T cells can promote local inflammation and bone remodeling through a variety of effector molecules such as IL-17 and IL-22. This evidence concerns the gene IL23A and enthesitis.